Description

1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride is a high-purity, fine chemical intermediate characterized by its difluorophenyl and amine hydrochloride functional groups. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where its specific fluorine substitution pattern is essential for modulating biological activity and metabolic stability. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance lipophilicity and target binding.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials.
• Bioconjugation and Probe Development: Useful in creating fluorescent probes or biochemical tools for diagnostic and research applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Product Name	1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	441074-78-8
Molecular Formula	C9H11F2N•HCl
Molecular Weight	207.65 g/mol
Synonyms	1-(3,4-Difluorophenyl)-1-propanamine hydrochloride; 3,4-Difluoro-α-ethylbenzylamine hydrochloride; 1-Amino-1-(3,4-difluorophenyl)propane hydrochloride; 3',4'-Difluoropropiophenone imine hydrochloride; Benzenemethanamine, 3,4-difluoro-α-ethyl-, hydrochloride; α-Ethyl-3,4-difluorobenzylamine hydrochloride; (3,4-Difluorophenyl)(ethyl)methanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and conformity to agreed specifications. Certificates of Analysis (COA) documenting all critical quality attributes are provided and available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.