Description

(4S)-4-Hydroxy-L-Proline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative essential for advanced biochemical synthesis. This compound is a critical chiral building block and intermediate in pharmaceutical research and development, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications ranging from peptide synthesis to drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly protease inhibitors and other bioactive compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the hydroxyproline residue, which is crucial for collagen stability and certain biological activities.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, metabolic pathway research, and as a component in cell culture media.
• Cosmeceutical Applications: Investigated for use in anti-aging and skin repair formulations due to its role as a precursor to collagen.
• Food & Nutrition Science: Employed in research related to collagen hydrolysates, nutraceuticals, and as a specialty dietary supplement ingredient.

Basic Information

Product Name	(4S)-4-Hydroxy-L-Proline Hydrochloride
CAS No.	441067-49-8
Molecular Formula	C5H9NO3·HCl
Molecular Weight	167.59 g/mol (Free base: 131.13)
Synonyms	L-Hydroxyproline Hydrochloride; (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride; 4-Hydroxy-L-proline HCl; Hyp-OH·HCl; trans-4-Hydroxy-L-proline hydrochloride; (4S)-4-Hydroxyproline Hydrochloride; L-4-Hydroxyproline Monohydrochloride
EINECS	Contact for details

Quality Control

Our (4S)-4-Hydroxy-L-Proline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and tests for residual solvents and heavy metals to ensure compliance with high-grade standards. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-70° to -80° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.