Description

Benzenamine, 4-(Trifluoromethyl)-2-[2-(Trimethylsilyl)ethynyl]- is a high-value, multi-functional aromatic amine building block featuring both a trifluoromethyl group and a protected ethynyl moiety. This compound is engineered to provide exceptional versatility in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the design of novel ligands for transition metal catalysis and organocatalysts.
• Fluorine Chemistry Research: An essential building block for studying structure-activity relationships (SAR) in medicinal and agrochemical discovery programs.
• Chemical Biology Probes: Used to create tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	Benzenamine, 4-(Trifluoromethyl)-2-[2-(Trimethylsilyl)ethynyl]-
CAS No.	440363-04-2
Molecular Formula	C12H14F3NSi
Molecular Weight	257.33 g/mol
Synonyms	4-(Trifluoromethyl)-2-[(trimethylsilyl)ethynyl]aniline; 2-[(Trimethylsilyl)ethynyl]-4-(trifluoromethyl)aniline; 4-(Trifluoromethyl)-2-((trimethylsilyl)ethynyl)benzenamine; 2-Ethynyl-4-(trifluoromethyl)aniline, TMS-protected; TMS-protected 2-Ethynyl-4-(trifluoromethyl)aniline; Aniline, 4-(trifluoromethyl)-2-[2-(trimethylsilyl)ethynyl]- (IUPAC); CAS 440363-04-2
EINECS	Contact for details

Quality Control

Our production of Benzenamine, 4-(Trifluoromethyl)-2-[2-(Trimethylsilyl)ethynyl]- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.