Description

Fmoc-Hyp-Obz CAS NO 439290-35-4 is a protected amino acid derivative, specifically an Fmoc-protected hydroxyproline benzyl ester, serving as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing the unique structural and functional properties of hydroxyproline into synthetic peptides, which is essential for mimicking collagen-like structures and studying protein-protein interactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, biochemical probes, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptides containing hydroxyproline residues.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting collagen-related disorders, fibrosis, and wound healing.
• Biochemical Research: Employed in the study of collagen structure, stability, and biosynthesis, as well as in probing enzyme-substrate interactions.
• Bioconjugation and Probe Synthesis: Acts as a precursor for creating labeled or modified peptides used in diagnostics and cellular imaging.
• Material Science: Utilized in the synthesis of peptide amphiphiles and self-assembling biomaterials for tissue engineering scaffolds.
• Custom Peptide Services: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide manufacturing.

Basic Information

Item	Detail
Product Name	Fmoc-Hyp-Obz
CAS No.	439290-35-4
Molecular Formula	C27H25NO6
Molecular Weight	459.49 g/mol
Synonyms	Fmoc-Hydroxyproline-OBzl; Fmoc-trans-4-Hydroxy-L-proline benzyl ester; N-(9-Fluorenylmethoxycarbonyl)-4-hydroxy-L-proline benzyl ester; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid benzyl ester; Fmoc-4(R)-Hyp-OBzl; Fmoc-Hyp(Bzl)-OH; Fmoc-L-Hyp-OBzl; Fmoc-4-hydroxyproline benzyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Hyp-Obz is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and chiral analysis to confirm stereochemical integrity. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.