Description

H-D-Cys(Trt)-Otbu·Hcl is a protected cysteine derivative, specifically the hydrochloride salt of the tert-butyl ester of S-trityl-D-cysteine. This compound is a critical building block in the synthesis of complex peptides, particularly those requiring the unique chemical properties of the D-cysteine enantiomer. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostics, and research tools. The product is supplied as a high-purity intermediate to ensure optimal performance in sensitive solid-phase and solution-phase peptide synthesis.

Application

• Pharmaceutical Peptide Synthesis: A key chiral building block for the incorporation of D-cysteine into therapeutic peptides, including hormone analogs and antimicrobial peptides.
• Research & Development: Used in academic and industrial R&D for studying peptide structure-activity relationships (SAR) and developing novel bioactive compounds.
• Bioconjugation Chemistry: The protected thiol group (after deprotection) serves as a handle for site-specific conjugation with maleimides, halogens, or other functional groups to create peptide-drug conjugates or labeled probes.
• Production of Peptide Libraries: Enables the creation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Synthesis of Cyclic and Constrained Peptides: The cysteine moiety is vital for forming disulfide bridges, which are crucial for stabilizing peptide conformations and enhancing biological activity.

Basic Information

Product Name	H-D-Cys(Trt)-Otbu·Hcl
CAS No.	439089-10-8
Molecular Formula	C26H29NO2S·HCl
Molecular Weight	464.04 g/mol
Synonyms	D-Cysteine, S-trityl-, 1,1-dimethylethyl ester, hydrochloride; H-D-Cys(Trt)-OtBu.HCl; tert-Butyl S-trityl-D-cysteinate hydrochloride; (2R)-2-amino-3-[tritylsulfanyl]propanoic acid tert-butyl ester hydrochloride; Boc-D-Cys(Trt)-OtBu (Note: Common naming convention, though this specific salt is HCl); Fmoc-D-Cys(Trt)-OH tert-butyl ester hydrochloride (Precursor naming); S-Trityl-D-cysteine tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Cys(Trt)-Otbu·Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.