Description

4-Hydroxy-2-(Pyrazin-2-Yl)-6-(Trifluoromethyl)Pyrimidine is a high-value heterocyclic building block characterized by its unique pyrimidine-pyrazine core and trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its structure imparts desirable biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine scaffold.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Material Science Research: Investigated as a potential building block for organic electronic materials due to its conjugated heterocyclic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	4-Hydroxy-2-(Pyrazin-2-Yl)-6-(Trifluoromethyl)Pyrimidine
CAS No.	438249-86-6
Molecular Formula	C9H5F3N4O
Molecular Weight	242.16 g/mol
Synonyms	4-Hydroxy-2-(pyrazin-2-yl)-6-(trifluoromethyl)pyrimidine; 2-(Pyrazin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol; 6-(Trifluoromethyl)-2-(2-pyrazinyl)-4-pyrimidinol; 4-Pyrimidinol, 2-(2-pyrazinyl)-6-(trifluoromethyl)-; CAS 438249-86-6
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-(Pyrazin-2-Yl)-6-(Trifluoromethyl)Pyrimidine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For custom synthesis projects, we adhere to cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.