Description

Fmoc-L-Thr(Tbu)-Ol CAS NO 438239-28-2 is a protected amino acid derivative, specifically an Fmoc-protected threonine tert-butyl ether, designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled and sequential assembly of complex peptides, ensuring high coupling efficiency and minimizing side reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/t-Bu strategy, enabling the synthesis of complex peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug candidates.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-conjugates used in diagnostic assays and imaging studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent for studies in biochemistry, molecular biology, and chemical biology focusing on protein structure-function relationships.
• Custom Peptide Service Providers: A core raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global market.

Basic Information

Item	Detail
Product Name	Fmoc-L-Thr(Tbu)-Ol
CAS No.	438239-28-2
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	Fmoc-Thr(tBu)-ol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-threoninol; (2S,3R)-3-[(tert-Butoxy)methyl]-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butan-2-ol; Fmoc-L-threonine(t-butyl)-ol; Fmoc-Thr(OtBu)-ol; Fmoc-Thr(tBu)-OH-ol; Fmoc-protected L-threoninol tert-butyl ether; N-α-Fmoc-O-tert-butyl-L-threoninol
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thr(Tbu)-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity (by HPLC), chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP environments for pharmaceutical intermediates and is compliant with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.