Description

5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethyl-substituted fused heterocyclic structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and antiviral drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel pyrazolopyrimidine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Oncology Drug Development: Serves as a core scaffold for potential kinase inhibitors and other targeted cancer therapies.
• Antiviral Agent Synthesis: Employed in the research and development of antiviral compounds.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents.
• Material Science Research: Investigated as a precursor for specialty chemicals and functional materials.

Basic Information

Product Name	5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid
CAS No.	438227-84-0
Molecular Formula	C10H5F4N3O2
Molecular Weight	299.16 g/mol
Synonyms	5,7-Bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 2-Pyrazolo[1,5-a]pyrimidinecarboxylic acid, 5,7-bis(difluoromethyl)-; 438227-84-0; 5,7-Bis(difluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxylic acid; 5,7-Difluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid; BDFP-2-COOH; Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 5,7-bis(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5,7-Bis-Difluoromethyl-Pyrazolo[1,5-A]Pyrimidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.