Description

4-Difluoromethyl-6-Methyl-Pyrimidine-2-Thiol is a specialized heterocyclic building block featuring a reactive thiol group and a difluoromethyl substituent. This compound matters as a key intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique fluorine-containing scaffold imparts desirable biological activity and metabolic stability. It is primarily needed by research and development chemists, process development teams, and manufacturers in the agrochemical and pharmaceutical industries for creating novel active ingredients.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel fungicides, herbicides, and insecticides, leveraging the bioactivity-enhancing properties of the difluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of new drug candidates, particularly in areas requiring fluorinated heterocycles.
• Chemical Synthesis Reagent: Serves as a versatile synthon in organic synthesis for constructing complex pyrimidine-based molecular architectures.
• Material Science Research: Investigated for potential applications in the development of advanced materials, such as ligands for catalysis or components in electronic materials.

Basic Information

Product Name	4-Difluoromethyl-6-Methyl-Pyrimidine-2-Thiol
CAS No.	438221-08-0
Molecular Formula	C6H6F2N2S
Molecular Weight	176.19 g/mol
Synonyms	2-Mercapto-4-(difluoromethyl)-6-methylpyrimidine; 4-(Difluoromethyl)-6-methyl-2-pyrimidinethiol; 4-(Difluoromethyl)-6-methylpyrimidine-2-thiol; 6-Methyl-4-(difluoromethyl)pyrimidine-2-thiol; 2-Pyrimidinethiol, 4-(difluoromethyl)-6-methyl-; 4-Difluoromethyl-6-methyl-2-mercaptopyrimidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards and customer specifications. Each batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) documenting all relevant parameters are available upon request, supporting your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.