Description

3-(2-Chloro-4-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzaldehyde core functionalized with halogenated phenoxymethyl and methoxy substituents. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drugs, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, leveraging its halogenated aromatic structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and photoactive compounds due to its conjugated aldehyde system.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and Industrial R&D: Used in research laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-(2-Chloro-4-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde
CAS No.	438220-87-2
Molecular Formula	C15H12ClFO3
Molecular Weight	294.70 g/mol
Synonyms	4-Methoxy-3-[(2-chloro-4-fluorophenoxy)methyl]benzaldehyde; 3-[(2-Chloro-4-fluorophenoxy)methyl]-4-methoxybenzaldehyde; Benzaldehyde, 3-[(2-chloro-4-fluorophenoxy)methyl]-4-methoxy-; 2-Chloro-4-fluoro-α-(4-methoxy-3-formylbenzyloxy)benzene; CAS 438220-87-2; 3-(2-Chloro-4-fluorophenoxymethyl)-4-methoxybenzaldehyde; 4-Methoxy-3-(2-chloro-4-fluorophenoxymethyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-4-Fluoro-Phenoxymethyl)-4-Methoxy-Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for trace impurities, residual solvents, and assay results. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert gas such as nitrogen or argon in sealed containers to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.