Description

1-Boc-4-(6-Aminopyrimidin-4-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring linked to an aminopyrimidine moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent kinase inhibitors due to its aminopyrimidine pharmacophore.
• Chemical Biology & Proteomics: Used in the creation of chemical probes for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the scale-up and production of candidate drugs under GMP conditions.
• Academic Research: Utilized in university and institutional labs for novel heterocyclic chemistry and drug discovery projects.
• Library Synthesis: A valuable input for generating diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	1-Boc-4-(6-Aminopyrimidin-4-Yl)Piperazine
CAS No.	436851-80-8
Molecular Formula	C13H20N6O2
Molecular Weight	292.34 g/mol
Synonyms	1-Boc-4-(6-aminopyrimidin-4-yl)piperazine; tert-Butyl 4-(6-aminopyrimidin-4-yl)piperazine-1-carboxylate; 4-(6-Amino-4-pyrimidinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(6-aminopyrimidin-4-yl)piperazine; 4-(6-Aminopyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; BOC-AP; 436851-80-8
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(6-Aminopyrimidin-4-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.