Description

4'-Trifluoromethoxy-Biphenyl-3-Ylamine is a high-purity aromatic amine featuring a trifluoromethoxy substituent at the 4′-position and an amino group at the 3-position of the biphenyl scaffold. This structural motif imparts enhanced metabolic stability, lipophilicity, and electron-withdrawing character—making it a critical building block for advanced pharmaceutical intermediates and functional materials. It is widely sought by R&D chemists and process development teams in global pharmaceutical, agrochemical, and OLED material manufacturing sectors. The compound is referenced as 4'-Trifluoromethoxy-Biphenyl-3-Ylamine CAS NO 436150-22-0 to ensure unambiguous identification across regulatory submissions and supply chain documentation.

Application

• Key intermediate in the synthesis of selective serotonin reuptake inhibitors (SSRIs) and kinase inhibitors
• Building block for next-generation liquid crystal monomers used in high-performance LCD displays
• Core scaffold in the development of fluorinated agrochemical active ingredients with improved environmental persistence profiles
• Functional dopant in emissive layers of blue-emitting phosphorescent OLED devices
• Structural motif in PET radiotracer precursors for oncology imaging agents (e.g., 18F-labeled analogs)
• Monomer for specialty polyimides exhibiting exceptional thermal stability and dielectric properties
• Reagent in cross-coupling reactions (e.g., Buchwald–Hartwig amination) for constructing biaryl amine libraries

Basic Information

Product Name	4'-Trifluoromethoxy-Biphenyl-3-Ylamine
CAS No.	436150-22-0
Molecular Formula	C13H10F3NO
Molecular Weight	253.22 g/mol
Synonyms	3-Amino-4′-trifluoromethoxybiphenyl; 3-(4-(Trifluoromethoxy)phenyl)aniline; 4′-Trifluoromethoxy-3-biphenylamine; 3-Amino-[1,1′-biphenyl]-4′-yl trifluoromethyl ether; NSC 759142; AKOS BBS-00003582; Z1125271120; 3-(4-Trifluoromethoxyphenyl)benzenamine
EINECS	Not listed (not pre-registered under REACH as of 2024)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested for identity (IR, 1H NMR), assay (HPLC), residual solvents (GC), heavy metals (ICP-MS), and related substances (HPLC with forced degradation studies). Manufacturing adheres to ISO 9001:2015 and follows cGMP-aligned practices suitable for pharmaceutical intermediate supply. Purity is confirmed ≥99.5% (HPLC area %), with strict control of genotoxic impurities per ICH M7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under inert atmosphere (nitrogen or argon) at 15–25°C. Keep away from oxidizing agents and sources of heat or ignition. Due to its susceptibility to oxidation, minimize exposure to air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥99.5%
Related Substances (HPLC)	≤0.5% total
Single Impurity	≤0.1%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Water (Karl Fischer)	≤0.5%
Identification (IR)	Conforms to reference standard
Identification (1H NMR)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.