Description

5-Methyl-7-Trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid is a high-value, multi-functional heterocyclic building block distinguished by its fused pyrazolopyrimidine core and trifluoromethyl group. This compound matters for its critical role in modern medicinal chemistry, where it serves as a privileged scaffold for designing novel bioactive molecules with enhanced metabolic stability and binding affinity. Pharmaceutical researchers and agrochemical developers need this advanced intermediate for the synthesis of potential drug candidates, particularly in therapeutic areas like oncology and central nervous system (CNS) disorders. Its unique structure offers significant potential for creating compounds with tailored physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the research and development of new active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group can improve biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a core structure for designing molecular probes to study enzyme function and biological pathways.
• Material Science Research: Potential precursor for specialty chemicals and advanced materials requiring specific heterocyclic architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	5-Methyl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid
CAS No.	436088-42-5
Molecular Formula	C10H10F3N3O2
Molecular Weight	261.20 g/mol
Synonyms	5-Methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 4,5,6,7-Tetrahydro-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 5-Methyl-7-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 4,5,6,7-tetrahydro-5-methyl-7-(trifluoromethyl)-; CAS 436088-42-5
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-7-Trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing all critical parameters are provided and available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept separate from incompatible materials. Keep the container tightly sealed when not in use to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.