Description

(Des-Bromo)-Neuropeptide B (1-23) (Human) is a synthetic peptide fragment corresponding to the N-terminal region of the human neuropeptide B, specifically lacking the bromine modification. This compound is a critical research tool for studying the structure-activity relationships and signaling pathways of the NPB/NPW receptor system. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neuroscience, metabolic disorders, and cardiovascular research.

Application

• Neuroscience Research: Investigation of the physiological roles of Neuropeptide B/W in the central nervous system, including appetite regulation, stress response, and neuroendocrine functions.
• Receptor Binding Studies: Used as a ligand or reference standard in competitive binding assays to characterize the NPBWR1 and NPBWR2 G-protein coupled receptors.
• Biochemical Assay Development: Serves as a key component in the development and validation of ELISA, RIA, or other immunoassays targeting the Neuropeptide B system.
• Structure-Activity Relationship (SAR) Analysis: Essential for mapping the bioactive core of Neuropeptide B by comparing the activity of this des-bromo fragment with the native, brominated form.
• Pharmaceutical Screening: Used in high-throughput screening campaigns to identify and evaluate potential agonists or antagonists for NPB receptors.
• Metabolic Disorder Research: Applied in studies exploring the link between neuropeptide signaling, energy homeostasis, and conditions like obesity and diabetes.

Basic Information

Product Name	(Des-Bromo)-Neuropeptide B (1-23) (Human)
CAS No.	434897-64-0
Molecular Formula	C₁₂₀H₁₉₇N₄₁O₃₅
Molecular Weight	2790.1 g/mol
Synonyms	Des-Bromo-Neuropeptide B (1-23); NPB (1-23), Des-Bromo-; Human Neuropeptide B (1-23) (Des-Bromo); H-Gly-Arg-Pro-Ser-Pro-Gly-Gln-Gly-Trp-Ala-Thr-Gly-His-Phe-Ile-Arg-Phe-Leu-Gln-Gln-Ala-Ser-Gly-Arg-NH₂; [Des-Bromo⁸]-Neuropeptide B (1-23); NPB (1-23) fragment; Neuropeptide B (Human, 1-23), Des-Bromo-
EINECS	Contact for details

Quality Control

Every batch of (Des-Bromo)-Neuropeptide B (1-23) (Human) is synthesized and purified under controlled conditions to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.