Description

5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyrimidine is a high-purity fluorinated pyrimidine derivative, a crucial building block in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a brominated pyrimidine ring with a trifluoroethoxy substituent, enabling precise modifications in complex molecular frameworks. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning the properties of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a versatile precursor for developing novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Used in the synthesis of specialty chemicals, liquid crystals, and advanced polymers where the introduction of fluorine and bromine functionalities is required.
• Chemical Biology & Proteomics: Employed as a molecular tag or a reactive handle in the design of chemical probes for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyrimidine
CAS No.	433683-47-7
Molecular Formula	C6H4BrF3N2O
Molecular Weight	257.01 g/mol
Synonyms	5-Bromo-2-(2,2,2-trifluoroethoxy)pyrimidine; 2-(2,2,2-Trifluoroethoxy)-5-bromopyrimidine; 5-Bromo-2-(trifluoroethoxy)pyrimidine; Pyrimidine, 5-bromo-2-(2,2,2-trifluoroethoxy)-; 433683-47-7; 5-Bromo-2-(2,2,2-trifluoroethyloxy)pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.