Description

n-(3,4-Difluorophenyl)-4-(2,4-Dimethoxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide CAS NO 431056-91-6 is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and production of new chemical entities (NCEs) for drug development.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• API Synthesis: Integral in multi-step synthetic routes for creating potential therapeutic agents, possibly in areas like oncology or neurology.
• Biochemical Research: May be employed as a tool compound or inhibitor in biochemical assays to study enzyme mechanisms or cellular pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for pioneering research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	n-(3,4-Difluorophenyl)-4-(2,4-Dimethoxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide
CAS No.	431056-91-6
Molecular Formula	C20H19F2N3O3S
Molecular Weight	419.45 g/mol
Synonyms	4-(2,4-Dimethoxyphenyl)-6-methyl-2-thioxo-N-(3,4-difluorophenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide; 1,2,3,4-Tetrahydropyrimidine-5-carboxamide, N-(3,4-difluorophenyl)-4-(2,4-dimethoxyphenyl)-6-methyl-2-thioxo-; 431056-91-6; Difluorophenyl Dimethoxyphenyl Methyl Thioxotetrahydropyrimidine Carboxamide; Tetrahydropyrimidine Carboxamide Derivative
EINECS	Contact for details

Quality Control

Our n-(3,4-Difluorophenyl)-4-(2,4-Dimethoxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support development projects with custom purity grades and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.