Description

(1S,2R)-Fmoc-2-Aminocyclohexane Carboxylic Acid CAS NO 430460-38-1 is a high-purity, non-proteinogenic amino acid derivative featuring a stereochemically defined cyclohexane backbone and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of conformationally constrained peptides and peptidomimetics, enabling the development of novel bioactive molecules with enhanced stability and specificity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of peptide-based therapeutics, diagnostic agents, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral amino acid component for introducing constrained cyclohexyl structures into peptide chains.
• Peptidomimetic Drug Discovery: For creating metabolically stable analogs of natural peptides to improve pharmacokinetic properties in therapeutic candidates.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse compound libraries for high-throughput screening.
• Protease Inhibitor Design: Used to synthesize transition-state analogs and inhibitors targeting specific enzyme classes.
• Conformationally Restricted Peptides: Essential for studying structure-activity relationships (SAR) by locking peptide backbones into specific conformations.
• Bioconjugation and Labeling: The Fmoc group allows for selective deprotection and further functionalization for probe or linker attachment.

Basic Information

Product Name	(1S,2R)-Fmoc-2-Aminocyclohexane Carboxylic Acid
CAS No.	430460-38-1
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-(1S,2R)-ACHC-OH; (1S,2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclohexanecarboxylic Acid; Fmoc-(1S,2R)-2-Aminocyclohexanecarboxylic Acid; (1S,2R)-2-(Fmoc-amino)cyclohexanecarboxylic Acid; trans-Fmoc-2-ACHC-OH (1S,2R); N-α-Fmoc-(1S,2R)-2-amino-cyclohexanecarboxylic acid; Fmoc-trans-2-ACHC-OH (1S,2R)
EINECS	Contact for details

Quality Control

Our (1S,2R)-Fmoc-2-Aminocyclohexane Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.