Description

Fmoc-Metyr(Bzl)-Oh CAS NO 428868-52-4 is a protected amino acid derivative, specifically an Fmoc-protected tyrosine analog with a benzyl (Bzl) group on the phenolic hydroxyl. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-purity, sequence-specific intermediates for producing therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated, stepwise construction of peptide chains, particularly those containing modified tyrosine residues.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation & Probe Development: Serves as a precursor for introducing tyrosine-derived linkers or fluorescent labels into proteins and other biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Institutional Research: A fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.

Basic Information

Item	Detail
Product Name	Fmoc-Metyr(Bzl)-Oh
CAS No.	428868-52-4
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-O-benzyl-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-benzyl-L-tyrosine; Fmoc-Tyr(Bzl)-OH; Fmoc-L-Tyrosine(Bzl)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-benzyloxyphenyl)propanoic acid; N-Fmoc-O-benzyl-L-tyrosine; Fmoc-Tyr(Bn)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Metyr(Bzl)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for GMP-compatible pharmaceutical ingredient production and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.