Description

4-Chloro-5-Methyl-6-Trifluoromethylpyrimidine is a high-value, multi-functional heterocyclic building block characterized by its reactive chloro and electron-withdrawing trifluoromethyl substituents. This compound is critical for facilitating rapid and efficient molecular diversification in advanced chemical synthesis, offering a strategic balance of reactivity and stability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Serves as a core building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials where the pyrimidine core contributes to desired electronic properties.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Nucleophilic Substitution: Facilitates the introduction of various amines, alkoxides, and thiols to create diverse pyrimidine libraries for high-throughput screening.
• Fluorine Chemistry: The -CF3 group provides metabolic stability and lipophilicity, making it a valuable motif in medicinal chemistry and drug design programs.

Basic Information

Product Name	4-Chloro-5-Methyl-6-Trifluoromethylpyrimidine
CAS No.	425394-59-8
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	4-Chloro-5-methyl-6-(trifluoromethyl)pyrimidine; 6-Trifluoromethyl-4-chloro-5-methylpyrimidine; 5-Methyl-4-chloro-6-trifluoromethylpyrimidine; 4-Chloro-6-trifluoromethyl-5-methylpyrimidine; Pyrimidine, 4-chloro-5-methyl-6-(trifluoromethyl)-; 425394-59-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Methyl-6-Trifluoromethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.