Description

5-Chloro-4-Hydroxy-6-Difluoromethylpyrimidine is a high-purity pyrimidine derivative serving as a critical synthetic intermediate in advanced chemical manufacturing. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and industrial-scale producers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking reliable, high-quality building blocks for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzymes and receptors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process chemistry optimization in laboratory settings.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the synthesis pathway for final active drug substances requiring a difluoromethylpyrimidine core.
• Material Science Precursor: Potential use in the development of specialty polymers and organic electronic materials.

Basic Information

Product Name	5-Chloro-4-Hydroxy-6-Difluoromethylpyrimidine
CAS No.	425394-28-1
Molecular Formula	C5H3ClF2N2O
Molecular Weight	192.54 g/mol
Synonyms	6-(Difluoromethyl)-5-chloro-4-hydroxypyrimidine; 5-Chloro-4-hydroxy-6-(difluoromethyl)pyrimidine; 4-Hydroxy-5-chloro-6-difluoromethylpyrimidine; 425394-28-1; Pyrimidine, 5-chloro-4-hydroxy-6-(difluoromethyl)-; 6-Difluoromethyl-5-chloro-4-hydroxypyrimidine
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Hydroxy-6-Difluoromethylpyrimidine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.