Description

4,5-Dichloro-6-difluoromethylpyrimidine is a high-value, multi-functional halogenated pyrimidine building block. This compound matters as a critical intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the fine chemical, crop protection, and active pharmaceutical ingredient (API) manufacturing sectors.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides and fungicides, leveraging the pyrimidine core for biological activity.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug candidates.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The chlorine atoms provide excellent handles for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for library synthesis.
• Nucleophilic Substitution: The difluoromethyl and chloro groups are amenable to substitution with various nucleophiles to create diverse pyrimidine derivatives.
• Chemical Synthesis Reference Standard: Used as a pure standard in analytical laboratories for method development and quality control.

Basic Information

Product Name	4,5-Dichloro-6-difluoromethylpyrimidine
CAS No.	425394-19-0
Molecular Formula	C5H2Cl2F2N2
Molecular Weight	198.98 g/mol
Synonyms	6-(Difluoromethyl)-4,5-dichloropyrimidine; 4,5-Dichloro-6-(difluoromethyl)pyrimidine; Pyrimidine, 4,5-dichloro-6-(difluoromethyl)-; 425394-19-0; 4,5-Dichloro-6-difluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 4,5-Dichloro-6-difluoromethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.