Description

5-Bromo-4-Chloro-6-Trifluoromethylpyrimidine is a high-value halogenated pyrimidine building block essential for advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and trifluoromethyl functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine core.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Nucleophilic Aromatic Substitution: The chlorine atom at the 4-position is susceptible to displacement by various nucleophiles, enabling diverse derivatization.
• Fluorine Chemistry Research: The stable trifluoromethyl group makes it a valuable compound for studying fluorine's effects on physicochemical properties and biological activity.

Basic Information

Product Name	5-Bromo-4-Chloro-6-Trifluoromethylpyrimidine
CAS No.	425392-76-3
Molecular Formula	C5HBrClF3N2
Molecular Weight	255.42 g/mol
Synonyms	4-Chloro-5-bromo-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-5-bromo-4-chloropyrimidine; 5-Bromo-4-chloro-6-(trifluoromethyl)pyrimidine; 4-Chloro-5-bromo-6-trifluoromethylpyrimidine; Pyrimidine, 5-bromo-4-chloro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-6-Trifluoromethylpyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.