Description

(2-Amino-4-(Trifluoromethyl)Pyrimidin-5-Yl)Methanol CAS NO 424789-62-8 is a high-purity pyrimidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its trifluoromethyl and amino-methanol functional groups, which are essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

This specialized pyrimidine intermediate is designed for high-value synthesis applications, including:

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Material Science Research: Potential building block for advanced organic electronic materials or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex target molecules.

Basic Information

Product Name	(2-Amino-4-(Trifluoromethyl)Pyrimidin-5-Yl)Methanol
CAS No.	424789-62-8
Molecular Formula	C6H6F3N3O
Molecular Weight	193.13 g/mol
Synonyms	5-(Hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-amine; 2-Amino-5-(hydroxymethyl)-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)pyrimidine-2,5-diamine, 5-methanol; (2-Amino-4-trifluoromethyl-pyrimidin-5-yl)-methanol; 5-Pyrimidinemethanol, 2-amino-4-(trifluoromethyl)-; 2-Amino-4-(trifluoromethyl)-5-pyridinemethanol; 424789-62-8
EINECS	Contact for details

Quality Control

Our (2-Amino-4-(Trifluoromethyl)Pyrimidin-5-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.