Description

5-Chloro-2-Nitro-4-Trifluoromethoxy-Phenylamine is a high-purity, multi-functional aromatic amine building block of significant commercial interest. This compound is valued for its unique trifluoromethoxy and nitro substituents, which impart specific electronic and steric properties crucial for advanced synthesis. It serves as a key intermediate for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly in the development of novel active ingredients. Its structural features make it essential for creating compounds with enhanced biological activity and stability.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of advanced herbicides, insecticides, and fungicides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Pharmaceutical Research: Serves as a versatile building block for constructing complex molecules in medicinal chemistry, particularly for developing candidates with specific receptor-binding profiles.
• Dye and Pigment Synthesis: Used in the production of specialized dyes and pigments, where the nitro and amine groups are key for color development and fastness properties.
• Material Science: Employed in the synthesis of advanced polymers and functional materials, such as liquid crystals or organic semiconductors, due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to create more complex biaryl amine structures.

Basic Information

Product Name	5-Chloro-2-Nitro-4-Trifluoromethoxy-Phenylamine
CAS No.	414637-23-3
Molecular Formula	C7H4ClF3N2O3
Molecular Weight	256.57 g/mol
Synonyms	2-Amino-4-chloro-5-nitro-1-(trifluoromethoxy)benzene; 4-Chloro-2-nitro-5-(trifluoromethoxy)aniline; 5-Chloro-2-nitro-4-(trifluoromethoxy)aniline; 1-Amino-2-chloro-5-nitro-4-(trifluoromethoxy)benzene; Benzenamine, 4-chloro-2-nitro-5-(trifluoromethoxy)-; 414637-23-3; 5-Chloro-2-nitro-4-trifluoromethoxyaniline
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Nitro-4-Trifluoromethoxy-Phenylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications for research and industrial use. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.