Description

3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the unique combination of a phenyl ring substituted with halogen atoms and a functionalized propanoic acid side chain, enabling precise molecular construction. This compound is primarily needed by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging its halogenated aromatic structure for bioactivity.
• Peptidomimetics Research: Serves as a constrained, non-proteinogenic amino acid analog for designing novel peptide-like molecules with enhanced stability and specificity.
• Chemical Biology Probes: Employed in the synthesis of specialized probes and ligands for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring a specific, functionalized aromatic β-amino acid framework.
• Academic & Institutional Research: Used in universities and research institutes for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoic Acid
CAS No.	412925-57-6
Molecular Formula	C9H9ClFNO2
Molecular Weight	217.62 g/mol
Synonyms	β-Amino-4-chloro-2-fluorohydrocinnamic acid; (R/S)-3-Amino-3-(4-chloro-2-fluorophenyl)propanoic acid; 3-Azaniumyl-3-(4-chloro-2-fluorophenyl)propanoate; 4-Chloro-2-fluoro-β-alanine, phenyl-; DL-3-Amino-3-(4-chloro-2-fluorophenyl)propionic acid; 3-(4-Chloro-2-fluorophenyl)-3-aminopropanoic acid; (4-Chloro-2-fluorophenyl)-β-alanine
EINECS	Contact for details

Quality Control

Our production of 3-Amino-3-(4-Chloro-2-Fluorophenyl)Propanoic Acid adheres to strict in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles is provided with each shipment. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.