Description

4-(Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of bioactive molecules targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those containing a functionalized piperidine scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides that require specific heterocyclic frameworks.
• Academic Research: Utilized in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized, non-commercial compounds for client projects.

Basic Information

Product Name	4-(Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	412293-91-5
Molecular Formula	C14H21N3O3
Molecular Weight	279.34 g/mol
Synonyms	1-Boc-4-(pyrimidin-2-yloxy)piperidine; tert-Butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate; 4-(2-Pyrimidinyloxy)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 4-(2-pyrimidinyloxy)-1-piperidinecarboxylate; 4-(Pyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester; 4-(2-Pyrimidinyloxy)piperidine-1-carboxylic Acid tert-Butyl Ester; Boc-4-(2-pyrimidyloxy)piperidine
EINECS	Contact for details

Quality Control

Our 4-(Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and mass spectrometry, to verify identity and purity. Certificates of Analysis (COA) are available for every batch and supplied upon request, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.