Description

Boc-D,L-5,5,5-Trifluoroleucine CAS NO 409333-67-1 is a protected, non-natural amino acid derivative featuring a trifluoromethyl group, which imparts unique steric and electronic properties to peptide backbones. This compound is a critical building block in medicinal chemistry and peptide research, enabling the modulation of peptide stability, lipophilicity, and metabolic resistance. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and advanced material researchers for the development of novel bioactive compounds and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the incorporation of fluorinated amino acids into peptide-based drug candidates, enhancing their metabolic stability and membrane permeability.
• Peptide Synthesis (Solid-Phase & Solution-Phase): Serves as a protected monomer for the controlled synthesis of fluorinated peptides and peptidomimetics in research and development.
• Agrochemical Research: Used in the design and synthesis of novel fluorinated bioactive molecules with potential herbicidal or insecticidal activity.
• Chemical Biology Probes: Enables the creation of labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular processes.
• Material Science: A precursor for specialty polymers and advanced materials where fluorine incorporation can alter surface properties and chemical resistance.

Basic Information

Product Name	Boc-D,L-5,5,5-Trifluoroleucine
CAS No.	409333-67-1
Molecular Formula	C₁₁H₁₈F₃NO₄
Molecular Weight	285.26 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-5,5,5-trifluoroleucine; (RS)-2-[(tert-Butoxycarbonyl)amino]-4,4,4-trifluoro-3-methylbutanoic acid; Boc-5,5,5-Trifluoro-DL-leucine; Boc-Trifluoroleucine; N-Boc-5,5,5-trifluoroleucine; (±)-N-Boc-5,5,5-trifluoroleucine; 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4,4,4-trifluoro-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our Boc-D,L-5,5,5-Trifluoroleucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.