Description

2-Propynal, 3-(2-Fluorophenyl)- (9Ci) is a specialized fluorinated alkyne building block of significant interest in advanced organic synthesis. Its core value lies in enabling the construction of complex molecular architectures, particularly through click chemistry and metal-catalyzed coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, where the introduction of a fluorinated phenylacetylene moiety can critically modulate biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in constructing advanced herbicide and pesticide molecules where fluorine substitution enhances efficacy and environmental profile.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Click Chemistry Reagent: An alkyne component for Huisgen 1,3-dipolar cycloaddition reactions, facilitating bioconjugation and polymer functionalization.
• Ligand Precursor: Used in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination methodologies and the effects of fluorine on reaction pathways.

Basic Information

Product Name	2-Propynal, 3-(2-Fluorophenyl)- (9Ci)
CAS No.	406687-57-8
Molecular Formula	C9H5FO
Molecular Weight	148.14 g/mol
Synonyms	3-(2-Fluorophenyl)propiolaldehyde; 2-Fluorophenylpropiolaldehyde; 2-Fluorophenylpropynal; (2-Fluorophenyl)propiolaldehyde; 2-Fluorobenzeneacrolein, 3-oxo-; Propiolaldehyde, 3-(2-fluorophenyl)-; 2-Fluorophenylacetylene carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-Propynal, 3-(2-Fluorophenyl)- is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.