Description

Fmoc Aeg-o-Ally Hcl CAS NO 406683-69-0 is a protected amino acid derivative, specifically an Fmoc-protected N-(2-aminoethyl)glycine derivative with an O-allyl side chain, supplied as its hydrochloride salt. This compound is a critical building block in the solid-phase synthesis of peptide nucleic acid (PNA) oligomers, enabling the creation of high-affinity, nuclease-resistant probes for molecular biology and diagnostics. It is essential for researchers and manufacturers in the fields of therapeutic development, genetic diagnostics, and advanced materials science who require precise and reliable monomers for constructing PNA backbones.

Application

• Peptide Nucleic Acid (PNA) Monomer Synthesis: Serves as a key protected monomer for the automated solid-phase assembly of PNA oligomers.
• Therapeutic Probe Development: Used in creating antisense and antigene agents for gene regulation and therapeutic applications.
• Molecular Diagnostics: Essential for manufacturing PNA-based probes for fluorescence in situ hybridization (FISH), PCR clamping, and biosensor applications.
• Bioconjugation and Labeling: The allyl protecting group offers a handle for further orthogonal chemical modifications and conjugation strategies.
• Academic and Industrial Research: A fundamental reagent for studying nucleic acid mimicry, duplex stability, and developing novel bio-recognition elements.
• High-Throughput Screening Assays: Used to develop PNA libraries for drug discovery and target identification platforms.

Basic Information

Product Name	Fmoc Aeg-o-Ally Hcl
CAS No.	406683-69-0
Molecular Formula	C24H28N2O5 • HCl
Molecular Weight	460.95 g/mol (Free base: 424.49)
Synonyms	Fmoc-Aeg(O-allyl)-OH•HCl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(2-{[(allyloxy)carbonyl]amino}ethyl)glycine hydrochloride; Fmoc-N-(2-((Allyloxycarbonyl)amino)ethyl)glycine hydrochloride; Fmoc-8-amino-3,6-dioxaoctanoic acid O-allyl ester hydrochloride; PNA Backbone Monomer Fmoc-Aeg(OAll)-OH•HCl; N-{2-[(Allyloxycarbonyl)amino]ethyl}-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine hydrochloride
EINECS	Contact for details

Quality Control

Our Fmoc Aeg-o-Ally Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure identity and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the material meets the stringent requirements for peptide synthesis and sensitive diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.