Description

Razaxaban (Hydrochloride) is a potent, selective, and orally active direct inhibitor of coagulation factor Xa (FXa). This compound is a key pharmaceutical intermediate and reference standard in the research and development of novel anticoagulant therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular and thrombosis research. The product is supplied with a guaranteed Certificate of Analysis to ensure research integrity and reproducibility.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug substance and product testing.
• Biochemical Research: Serves as a critical tool for studying the coagulation cascade, specifically the role and inhibition of Factor Xa.
• Preclinical Development: Employed as a lead compound or benchmark in the discovery and optimization of new antithrombotic agents.
• Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of FXa inhibitors.
• Academic Research: Facilitates fundamental research into hemostasis, thrombosis mechanisms, and related cardiovascular pathologies.

Basic Information

Product Name	Razaxaban (Hydrochloride)
CAS No.	405940-76-3
Molecular Formula	C19H19ClN6O3
Molecular Weight	414.85 g/mol
Synonyms	Razaxaban HCl; 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride; DPC 906; BMS-561389; BMS 561389; Factor Xa Inhibitor (Razaxaban); 4-(4-{[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
EINECS	Contact for details

Quality Control

Our Razaxaban (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from tests such as HPLC assay, related substances, residual solvents, and identification (IR, NMR). Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.