Description

2-(4-Fluoro-Phenyl)-Ethanesulfonyl Chloride is a specialized organosulfur building block of significant importance in advanced organic synthesis. This compound matters as a key reagent for introducing the 2-(4-fluorophenyl)ethanesulfonyl moiety, a valuable functional group in medicinal chemistry and materials science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition or acting as protease inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorophenylsulfonyl group enhances biological activity and metabolic stability.
• Chemical Biology Probe Development: Serves as a versatile handle for labeling proteins or creating activity-based probes (ABPs) due to its reactive sulfonyl chloride group.
• Polymer & Materials Science: Employed as a monomer or cross-linking agent in the production of specialty polymers, such as sulfonated polyaryletherketones for membrane applications.
• Ligand & Catalyst Development: Utilized to synthesize novel sulfonamide-based ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A key building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(4-Fluoro-Phenyl)-Ethanesulfonyl Chloride
CAS No.	405219-34-3
Molecular Formula	C8H8ClFO2S
Molecular Weight	222.66 g/mol
Synonyms	2-(4-Fluorophenyl)ethanesulfonyl chloride; 4-Fluorophenethylsulfonyl chloride; 2-(4-Fluorophenyl)ethane-1-sulfonyl chloride; 1-(Chlorosulfonyl)-2-(4-fluorophenyl)ethane; p-Fluorophenethylsulfonyl chloride; 4-Fluoro-α-toluenesulfonyl chloride; 2-(p-Fluorophenyl)ethylsulfonyl chloride; 405219-34-3
EINECS	Contact for details

Quality Control

Our 2-(4-Fluoro-Phenyl)-Ethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.