Description

(Pyr1)-Urotensin II CAS NO 405136-99-4 is a potent synthetic peptide analog of the endogenous vasoactive peptide Urotensin II, designed for enhanced stability and biological activity. This compound is a critical research tool for investigating the urotensinergic system, which plays a significant role in cardiovascular regulation and related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, metabolic disorders, and central nervous system research.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies targeting the UT receptor (GPR14) to understand its role in vasoconstriction, cardiac function, and fibrosis.
• Drug Discovery & Development: Serves as a key lead compound or molecular probe for screening and developing novel therapeutics for hypertension, heart failure, and atherosclerosis.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays (e.g., calcium flux), and signal transduction pathway analysis to elucidate mechanism of action.
• Academic & Clinical Research: Facilitates basic science investigations into the physiological and pathophysiological roles of the urotensin system in various organ systems.
• Peptide Chemistry Studies: Used as a model compound for studying structure-activity relationships (SAR) and stability of modified peptides.

Basic Information

Product Name	(Pyr1)-Urotensin II
CAS No.	405136-99-4
Molecular Formula	C106H146N26O28S2
Molecular Weight	~2296.6 g/mol
Synonyms	Pyr-Urotensin II; [Pyr1]Urotensin II; H-Pyr-Asn-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (cyclic 4-9 disulfide); Urotensin II (human, mouse, rat); UII; U-II; hUII; GPR14 Ligand
EINECS	Contact for details

Quality Control

Our (Pyr1)-Urotensin II is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for peptide synthesis, and our quality system supports compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. After reconstitution, aliquot and store frozen at -80°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.