Description

4-(Chloromethyl)-n-4-Methyl-3-[(4-(3-Pyridinyl)-2-Pyrimidinyl)Amino]Phenylbenzamide Hydrochloride is a high-purity, non-GMP organic intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in the development of novel small-molecule drugs for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced kinase inhibitor candidates for targeted cancer therapies.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical raw material in the scale-up and process development of active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Research: Utilized in biochemical assays to study enzyme inhibition mechanisms and cellular signaling pathways.

Basic Information

Product Name	4-(Chloromethyl)-n-4-Methyl-3-[(4-(3-Pyridinyl)-2-Pyrimidinyl)Amino]Phenylbenzamide Hydrochloride
CAS No.	404844-10-6
Molecular Formula	C25H22ClN5O • HCl
Molecular Weight	496.84 g/mol
Synonyms	4-(Chloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide hydrochloride; BMS-354825 Impurity; Dasatinib Related Compound; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide (common mis-association); 4-(Chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide hydrochloride; UNII-9L5L1F544K; 404844-10-6
EINECS	Contact for details

Quality Control

Our 4-(Chloromethyl)-n-4-Methyl-3-[(4-(3-Pyridinyl)-2-Pyrimidinyl)Amino]Phenylbenzamide Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.