Description

4-Difluoromethylphenol is a fluorinated phenolic compound that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both a phenol and a difluoromethyl group, makes it a critical intermediate for introducing fluorine atoms into target molecules, thereby modulating their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs where fluorine substitution is used to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethylphenol moiety can contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies, leveraging the polarity and steric effects of the fluorine atoms.
• Polymer Modification: Acts as a monomer or additive for creating specialty polymers with enhanced chemical resistance, thermal stability, or specific surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a substrate for further functionalization to create complex, fluorinated aromatic compounds for research and development.

Basic Information

Product Name	4-Difluoromethylphenol
CAS No.	403648-76-0
Molecular Formula	C7H6F2O
Molecular Weight	144.12 g/mol
Synonyms	4-(Difluoromethyl)phenol; p-(Difluoromethyl)phenol; Phenol, 4-(difluoromethyl)-; 1-Hydroxy-4-(difluoromethyl)benzene; Difluoromethylphenol; 4-Hydroxybenzylidene difluoride
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethylphenol is produced and tested under a strict quality management system to ensure consistency and reliability for your critical processes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and your specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its phenolic nature, ensure proper handling procedures are followed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.