Description

4,6-Quinazolinediamine, N4-(3-Chloro-4-Fluorophenyl)-7-[[(3R)-Tetrahydro-3-Furanyl]Oxy]- is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery and development. Its complex heterocyclic structure, featuring a quinazoline core with specific chiral and halogenated substituents, makes it a critical building block for synthesizing targeted therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel, potent kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard and active probe in enzymatic assays and structure-activity relationship (SAR) studies.
• Drug Discovery Programs: Integral to medicinal chemistry efforts for designing and optimizing lead compounds with enhanced selectivity and efficacy.
• API Development: Employed in the process development and scale-up of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Academic Research: Utilized in university and institutional labs for investigating novel signaling pathways and drug mechanisms of action.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for client projects.

Basic Information

Product Name	4,6-Quinazolinediamine, N4-(3-Chloro-4-Fluorophenyl)-7-[[(3R)-Tetrahydro-3-Furanyl]Oxy]-
CAS No.	402855-03-2
Molecular Formula	C18H17ClFN5O2
Molecular Weight	389.81 g/mol
Synonyms	N4-(3-Chloro-4-fluorophenyl)-7-[(3R)-oxolan-3-yl]oxyquinazoline-4,6-diamine; (3R)-3-({4-Amino-6-[(3-chloro-4-fluorophenyl)amino]quinazolin-7-yl}oxy)oxolane; 402855-03-2; 7-[(3R)-Tetrahydrofuran-3-yloxy]-N4-(3-chloro-4-fluorophenyl)quinazoline-4,6-diamine; A specific kinase inhibitor intermediate. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our 4,6-Quinazolinediamine derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to exacting internal standards, specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.