Description

5-Bromo-2,4-Dioxo-3,4-Dihydro-2H-Pyrimidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of nucleoside analogs and other active pharmaceutical ingredients (APIs) targeting viral and oncological diseases. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of modified nucleosides and nucleotides for antiviral and anticancer drug candidates.
• Antiviral Drug Development: Used in research and production of compounds targeting viruses such as hepatitis and herpes.
• Oncology Research: Serves as a building block for creating novel chemotherapeutic agents and targeted cancer therapies.
• Protease Inhibitor Synthesis: Employed in the construction of complex molecular scaffolds for protease inhibitor development.
• Chemical Biology & Medicinal Chemistry: A valuable reagent for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Custom Synthesis & Scale-Up: Supplied for process development, optimization, and commercial-scale manufacturing under cGMP guidelines where required.

Basic Information

Item	Details
Product Name	5-Bromo-2,4-Dioxo-3,4-Dihydro-2H-Pyrimidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	402848-99-1
Molecular Formula	C9H11BrN2O4
Molecular Weight	291.10 g/mol
Synonyms	5-Bromo-1-(tert-butoxycarbonyl)uracil; 5-Bromo-1-Boc-uracil; 5-Bromouracil-1-carboxylic acid tert-butyl ester; 1-Boc-5-bromouracil; tert-Butyl 5-bromo-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxylate; 5-Br-1-Boc-Ura; 5-Bromo-1-(tert-butoxycarbonyl)-2,4(1H,3H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Dioxo-3,4-Dihydro-2H-Pyrimidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment. Our quality commitment supports applications requiring material for research, development, and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.