Description

1-T-Butoxycarbonylthymine is a key protected nucleobase derivative, specifically a thymine molecule functionalized with a tert-butoxycarbonyl (Boc) protecting group. This compound is essential for the controlled synthesis of oligonucleotides and nucleoside analogs, where it prevents unwanted side reactions during complex chemical assembly. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the development of novel therapeutics, diagnostic probes, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antiviral and anticancer nucleoside drugs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase assembly of DNA and RNA sequences.
• Prodrug Development: Used to create prodrug forms of nucleoside analogs, improving bioavailability and pharmacokinetics.
• Bioconjugation & Labeling: Facilitates the site-specific attachment of thymine derivatives to peptides, proteins, or other molecules for diagnostic applications.
• Chemical Biology Research: A valuable tool for studying nucleic acid structure, function, and enzyme interactions.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value specialty chemicals for research and development.

Basic Information

Product Name	1-T-Butoxycarbonylthymine
CAS No.	402848-98-0
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	1-Boc-thymine; 1-(tert-Butoxycarbonyl)thymine; Thymine-1-carboxylic acid tert-butyl ester; N-Boc-thymine; 5-Methyl-1-[(2-methyl-2-propanyl)oxycarbonyl]-2,4(1H,3H)-pyrimidinedione; 1-(tert-Butoxycarbonyl)-5-methyluracil; Boc-Thymine; 1-N-Boc-5-methyluracil
EINECS	Contact for details

Quality Control

Our 1-T-Butoxycarbonylthymine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.