Description

L-Leucine, 5-Amino-5-Oxo-, (4R)- (9Ci) is a specialized, high-purity derivative of the essential amino acid L-leucine, identified by CAS number 402579-68-4. This compound is valued for its role as a key chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel therapeutics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug molecules, particularly peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies and metabolic pathway investigations.
• Proteomics & Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to introduce specific structural motifs.
• Asymmetric Synthesis: Acts as a starting material or auxiliary for constructing stereochemically defined compounds in medicinal chemistry.
• Reference Standard: Utilized in analytical laboratories for method development and quality control (HPLC, LC-MS) of related substances.
• Nutraceutical R&D: Investigated for potential applications in specialized amino acid formulations and metabolic supplements.

Basic Information

Product Name	L-Leucine, 5-Amino-5-Oxo-, (4R)- (9Ci)
CAS No.	402579-68-4
Molecular Formula	C6H12N2O2
Molecular Weight	144.17 g/mol
Synonyms	(4R)-5-Amino-5-oxoleucine; (R)-2-Amino-4-methylpentanoic acid 5-amide; 5-Amino-5-oxo-L-leucine; L-2-Amino-4-methyl-5-oxovaleramide; 5-Oxo-L-norleucinamide; (4R)-5-Amino-5-oxo-2-aminopentanoic acid; 5-Amino-5-oxonorleucine
EINECS	Contact for details

Quality Control

Our L-Leucine, 5-Amino-5-Oxo-, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.