Description

Ac-Phe(4-Nh2)-Oh is a protected amino acid derivative, specifically an N-acetylated phenylalanine analog with an amino group at the para position. This compound serves as a critical building block in peptide synthesis and medicinal chemistry, enabling the introduction of modified aromatic side chains for structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides and bioactive molecules.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues.
• Bioconjugation & Probe Development: The aromatic amine group allows for functionalization, making it useful for creating fluorescent probes or antibody-drug conjugates (ADCs).
• Chemical Biology Research: Employed in studying enzyme-substrate interactions and protein engineering due to its unique side-chain functionality.
• Material Science: Potential monomer for creating specialized polymers with specific aromatic and hydrogen-bonding characteristics.

Basic Information

Item	Details
Product Name	Ac-Phe(4-Nh2)-Oh
CAS No.	402497-81-8
Molecular Formula	C11H14N2O3
Molecular Weight	222.24 g/mol
Synonyms	N-Acetyl-4-aminophenylalanine; N-Acetyl-L-4-aminophenylalanine; Ac-4-Amino-Phe-OH; (2S)-2-Acetamido-3-(4-aminophenyl)propanoic acid; N-Acetyl-4-amino-L-phenylalanine; Fmoc-Phe(4-NH2)-OH precursor; Protected 4-aminophenylalanine derivative
EINECS	Contact for details

Quality Control

Our Ac-Phe(4-Nh2)-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm enantiomeric purity, and spectroscopic identification (NMR, IR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.