Description

2-Methoxyethyl 4-(3-Chlorophenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within the dihydropyrimidinone class. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of target drug molecules, especially those with dihydropyrimidinone scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with potential biological activity.
• API Synthesis: Serves as a core structural unit in the production of Active Pharmaceutical Ingredients for various therapeutic areas.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in universities and research institutes for studying heterocyclic chemistry and reaction mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	2-Methoxyethyl 4-(3-Chlorophenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate
CAS No.	402488-09-9
Molecular Formula	C15H17ClN2O4
Molecular Weight	324.76 g/mol
Synonyms	2-Methoxyethyl 4-(3-chlorophenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate; 4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 2-methoxyethyl ester; 5-Carboxy-4-(3-chlorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one 2-methoxyethyl ester; Dihydropyrimidinone derivative CAS 402488-09-9; Biginelli reaction product; 3,4-Dihydropyrimidin-2(1H)-one-5-carboxylate ester
EINECS	Contact for details

Quality Control

Our 2-Methoxyethyl 4-(3-Chlorophenyl)-6-Methyl-2-Oxo-3,4-Dihydro-1H-Pyrimidine-5-Carboxylate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.