Description

1-(4-Trifluoromethyl-Pyrimidin-2-Yl)-Piperidin-4-Ol is a high-value pharmaceutical intermediate and building block characterized by its unique piperidine-pyrimidine core and trifluoromethyl substituent. This compound matters for its critical role in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular interactions. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop novel drug candidates in oncology, central nervous system (CNS) disorders, and other specialized fields.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Kinase Inhibitor Development: Serves as a core scaffold for the development of protein kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and enzyme functions.
• Agrochemical Synthesis: Acts as an intermediate in the development of advanced crop protection agents and pesticides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(4-Trifluoromethyl-Pyrimidin-2-Yl)-Piperidin-4-Ol
CAS No.	401930-07-2
Molecular Formula	C10H12F3N3O
Molecular Weight	247.22 g/mol
Synonyms	4-Piperidinol, 1-[2-(4-(trifluoromethyl)pyrimidinyl]-; 1-(4-(Trifluoromethyl)pyrimidin-2-yl)piperidin-4-ol; 2-(4-Hydroxypiperidin-1-yl)-4-(trifluoromethyl)pyrimidine; 401930-07-2; 1-(4-Trifluoromethyl-2-pyrimidinyl)-4-piperidinol; 4-Hydroxy-1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidine
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethyl-Pyrimidin-2-Yl)-Piperidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.