Description

(S)-3-(Fmoc-Amino)-n-Trityl-Adipic Acid 6-Amide is a sophisticated, high-purity chiral building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control in the construction of complex molecules. It is primarily utilized in the pharmaceutical and biotechnology industries for the solid-phase and solution-phase synthesis of peptides and peptidomimetics, where its orthogonal protecting groups (Fmoc and Trityl) offer strategic flexibility.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid derivative for the controlled assembly of peptide chains on resin.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and peptide conjugates in solution, leveraging its selective protecting groups.
• Peptidomimetic Drug Discovery: Acts as a crucial intermediate for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Synthesis of Modified Amino Acids: Used to introduce specific, side-chain modified amino acid units into target sequences.
• Bioconjugation and Labeling: Functions as a linker or spacer molecule in the conjugation of peptides to other biomolecules, dyes, or solid surfaces.

Basic Information

Product Name	(S)-3-(Fmoc-Amino)-n-Trityl-Adipic Acid 6-Amide
CAS No.	401915-55-7
Molecular Formula	C45H40N2O5
Molecular Weight	688.82 g/mol
Synonyms	Fmoc-Ada(Trt)-OH; Nα-Fmoc-Nδ-trityl-L-2-aminoadipic acid 6-amide; (2S)-5-[(Tritylamino)methyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamide; L-2-Aminoadipic acid 6-amide, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-triphenylmethyl-; Fmoc-Ada(Trt)-NH2; Fmoc-2-amino-5-[(tritylamino)methyl]pentanamide
EINECS	Contact for details

Quality Control

Every batch of (S)-3-(Fmoc-Amino)-n-Trityl-Adipic Acid 6-Amide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products meet the stringent requirements for advanced pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) documenting purity (by HPLC), chiral purity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.