Description

2,4-Difluorophenyl Chloroformate is a versatile and highly reactive chemical building block, primarily used as an intermediate in organic synthesis. Its value lies in its ability to efficiently introduce the 2,4-difluorophenyl carbamate or carbonate moiety, which is crucial for modifying the properties of target molecules. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create active ingredients with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl group can improve lipophilicity and target binding.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of fluorinated aromatic compounds used in electronic display technologies.
• Peptide & Protein Modification: Employed as a coupling reagent or protecting group agent in peptide synthesis and bioconjugation strategies.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for exploring new synthetic routes and molecular entities.

Basic Information

Item	Detail
Product Name	2,4-Difluorophenyl Chloroformate
CAS No.	400900-00-7
Molecular Formula	C7H3ClF2O2
Molecular Weight	192.55 g/mol
Synonyms	Chloroformic Acid 2,4-Difluorophenyl Ester; 2,4-Difluorophenyl Carbonochloridate; Carbonochloridic Acid, 2,4-Difluorophenyl Ester; 2,4-DFPC; 2,4-Difluorophenyl Chlorocarbonate; (2,4-Difluorophenoxy)carbonyl Chloride
EINECS	Contact for details

Quality Control

Our 2,4-Difluorophenyl Chloroformate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.