Description

Ac-Val-Met-Leu-Psi[Choh-Ch]-Val-Ala-Glu-Phe-Oh is a synthetic peptide derivative, specifically a peptidomimetic incorporating a reduced amide bond (Psi[CHOH-CH2]) to enhance metabolic stability. This compound is a valuable research-grade intermediate for the development of novel protease inhibitors and therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and biotechnology companies focused on drug discovery and biochemical pathway analysis.

Application

• Protease Inhibitor Research: Serves as a key scaffold or intermediate in the design and synthesis of inhibitors targeting specific proteolytic enzymes.
• Drug Discovery & Development: Used as a building block in medicinal chemistry programs to create peptide-based therapeutics with improved pharmacokinetic properties.
• Biochemical Tool Compound: Acts as a substrate analog or inhibitor in enzymatic assays to study protease function and mechanism of action.
• Structure-Activity Relationship (SAR) Studies: The reduced amide bond moiety is critical for investigating the impact of backbone modifications on biological activity and stability.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for fundamental research in biochemistry and molecular biology.

Basic Information

Product Name	Ac-Val-Met-Leu-Psi[Choh-Ch]-Val-Ala-Glu-Phe-Oh
CAS No.	400836-30-8
Molecular Formula	C48H78N8O12S
Molecular Weight	991.25 g/mol
Synonyms	N-Acetyl-L-valyl-L-methionyl-L-leucyl-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-valyl-L-alanyl-L-α-glutamyl-L-phenylalaninol; Ac-Val-Met-Leu-psi[CH(OH)CH2]-Val-Ala-Glu-Phe-ol; Reduced Amide Bond Peptide Inhibitor; Peptidomimetic Protease Inhibitor Intermediate; STAT3 Inhibitor Peptide Derivative; STAT3 Signaling Inhibitor; STAT3-S3I-201 Analog; Research Peptide 400836-30-8
EINECS	Contact for details

Quality Control

Our Ac-Val-Met-Leu-Psi[Choh-Ch]-Val-Ala-Glu-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.