Description

(2-Methoxy-5-(Trifluoromethyl)Phenyl)Methanamine is a high-purity aromatic amine building block featuring a methoxy and a trifluoromethyl substituent on the phenyl ring. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable metabolic stability and bioavailability. It is primarily sought by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes in diagnostic and research applications.

Basic Information

Product Name	(2-Methoxy-5-(Trifluoromethyl)Phenyl)Methanamine
CAS No.	400771-42-8
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	1-(2-Methoxy-5-(trifluoromethyl)phenyl)methanamine; [2-Methoxy-5-(trifluoromethyl)phenyl]methanamine; 2-Methoxy-5-(trifluoromethyl)benzylamine; α-Amino-2-methoxy-α,α,α-trifluoro-p-xylene; 5-(Trifluoromethyl)-2-methoxybenzylamine; (2-Methoxy-5-trifluoromethylphenyl)methylamine; 2-Methoxy-α-(trifluoromethyl)benzylamine
EINECS	Contact for details

Quality Control

Our (2-Methoxy-5-(Trifluoromethyl)Phenyl)Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.