Description

(3,5-Bis(Trifluoromethyl)Phenyl)Methanesulfonyl Chloride is a high-value, specialized organosulfur building block characterized by its reactive sulfonyl chloride group and electron-deficient aromatic system. This compound is essential for the synthesis of advanced sulfonamide derivatives, which are key pharmacophores in modern medicinal chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A critical precursor for synthesizing sulfonamide-based drug candidates, particularly in oncology, antiviral, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide moiety enhances biological activity and selectivity.
• Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with unique surface properties or chemical resistance.
• Chemical Biology & Proteomics: Employed as an electrophilic probe or labeling reagent for studying protein interactions and enzyme inhibition.
• Catalyst & Ligand Development: Used to construct sophisticated ligands for transition metal catalysis, leveraging the electron-withdrawing trifluoromethyl groups.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(3,5-Bis(Trifluoromethyl)Phenyl)Methanesulfonyl Chloride
CAS No.	400770-85-6
Molecular Formula	C10H5ClF6O2S
Molecular Weight	338.65 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzenemethanesulfonyl chloride; [3,5-Bis(trifluoromethyl)phenyl]methanesulfonyl chloride; α,α,α,α',α',α'-Hexafluoro-3,5-xylylmethanesulfonyl chloride; 3,5-Bis(trifluoromethyl)benzylsulfonyl chloride; (3,5-Di(trifluoromethyl)phenyl)methanesulfonyl chloride; 1-(Chlorosulfonylmethyl)-3,5-bis(trifluoromethyl)benzene; NSC 405124
EINECS	Contact for details

Quality Control

Every batch of (3,5-Bis(Trifluoromethyl)Phenyl)Methanesulfonyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key purity and identity parameters. Our commitment to supply chain integrity and traceability supports compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.