Description

4'-Trifluoromethyl-Biphenyl-3-Ylamine is a high-purity aromatic amine derivative featuring a biphenyl core substituted with a trifluoromethyl group and an amine functionality. This compound is a critical pharmaceutical intermediate and advanced building block for the synthesis of complex molecules, valued for its ability to modulate the physicochemical properties of target compounds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and charge-transport layers in electronic displays and devices.
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve thermal stability, chemical resistance, and optical properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Buchwald-Hartwig amination) and as a precursor for heterocyclic compounds.
• Research & Development: Essential for medicinal chemistry programs and material science research in academic and industrial laboratories.

Basic Information

Product Name	4'-Trifluoromethyl-Biphenyl-3-Ylamine
CAS No.	400747-98-0
Molecular Formula	C13H10F3N
Molecular Weight	237.22 g/mol
Synonyms	3-Amino-4'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-3-amine, 4'-(trifluoromethyl)-; 4'-(Trifluoromethyl)biphenyl-3-amine; 3-Amino-4'-trifluoromethylbiphenyl; Biphenyl-3-amine, 4'-trifluoromethyl-; 4'-Trifluoromethyl-3-aminobiphenyl; 3-(4-Trifluoromethylphenyl)aniline
EINECS	Contact for details

Quality Control

Our 4'-Trifluoromethyl-Biphenyl-3-Ylamine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.