Description

N5-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-D-Ornithine is a protected derivative of the non-proteinogenic amino acid D-ornithine, featuring the acid-labile Fmoc (9-fluorenylmethoxycarbonyl) protecting group on its side-chain amine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of D-ornithine residues with orthogonal side-chain protection. It is essential for researchers and manufacturers developing novel peptides for pharmaceutical research, diagnostic applications, and biochemical studies, where precise stereochemistry and side-chain functionality are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of D-ornithine into peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates, antimicrobial peptides (AMPs), and hormone analogs.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of peptide-protein or peptide-small molecule conjugates due to its reactive side-chain after deprotection.
• Biochemical Probes: Incorporation into labeled peptides for studying enzyme-substrate interactions, receptor binding, and cellular uptake mechanisms.
• Material Science: Building block for peptide-derived polymers and biomaterials where the unique properties of D-amino acids are required.

Basic Information

Product Name	N5-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-D-Ornithine
CAS No.	400746-61-4
Molecular Formula	C20H20N2O4
Molecular Weight	352.39 g/mol
Synonyms	Fmoc-D-ornithine; Nδ-Fmoc-D-ornithine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoic acid; D-Ornithine, N5-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Orn-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-ornithine
EINECS	Contact for details

Quality Control

Our N5-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-D-Ornithine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.