Description

(2R,4R)-2-Amino-4-Thiophen-2-Ylmethyl-Pentanedioic Acid is a high-purity chiral amino acid derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block or intermediate for the development of novel therapeutic agents, particularly in areas requiring stereochemical precision. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in peptide mimetics, protease inhibitors, and other bioactive molecule development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for targeted therapies.
• Peptidomimetics: Used in the design and synthesis of peptide analogs with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural component for inhibitors targeting specific enzymes.
• Chemical Biology Research: Employed as a tool compound or labeled precursor in biochemical pathway studies.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective chemical reactions.
• Reference Standard: Sourced for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(2R,4R)-2-Amino-4-Thiophen-2-Ylmethyl-Pentanedioic Acid
CAS No.	400625-57-2
Molecular Formula	C11H15NO4S
Molecular Weight	257.30 g/mol
Synonyms	(2R,4R)-2-Amino-4-((thiophen-2-yl)methyl)pentanedioic acid; (2R,4R)-4-(Thiophen-2-ylmethyl)glutamic acid; (2R,4R)-HomoThioGlu; 2-Amino-4-(2-thienylmethyl)pentanedioic acid, (2R,4R)-; L-threo-4-(2-Thienyl)homo glutamate; (2R,4R)-2-Amino-4-(thiophen-2-ylmethyl)glutaric acid; A building block for protease inhibitors
EINECS	Contact for details

Quality Control

Our (2R,4R)-2-Amino-4-Thiophen-2-Ylmethyl-Pentanedioic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.