Description

2-Chloro-4-Methylsulfanyl-Pyrimidine is a versatile heterocyclic building block characterized by its reactive chloro and methylsulfanyl substituents. This compound is essential for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functional groups into pyrimidine-based scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that leverage the pyrimidine core for biological activity.
• Chemical Research & Development: Serves as a versatile building block in organic synthesis for creating novel heterocyclic compounds and ligands.
• Material Science: Potential use in the development of organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The chloro group makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Nucleophilic Substitution: The methylsulfanyl group can be modified or displaced to introduce a variety of other functional moieties.

Basic Information

Product Name	2-Chloro-4-Methylsulfanyl-Pyrimidine
CAS No.	49844-93-1
Molecular Formula	C5H5ClN2S
Molecular Weight	160.62 g/mol
Synonyms	2-Chloro-4-(methylthio)pyrimidine; 4-(Methylthio)-2-chloropyrimidine; 2-Chloro-4-methylsulfanylpyrimidine; 2-Chloro-4-methylmercaptopyrimidine; 4-Methylsulfanyl-2-chloropyrimidine; Pyrimidine, 2-chloro-4-(methylthio)-; 2-Chloro-4-(methylsulfanyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Methylsulfanyl-Pyrimidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, and our quality management system supports compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.